To date, two estrogen receptors have been identified. They vary in proportion from tissue to tissue. Circulating estrogens modulate the pituitary secretion of the gonadotropins, luteinizing hormone LH and follicle stimulating hormone FSH , through a negative feedback mechanism. Estrogen replacement therapy acts to reduce the elevated levels of these hormones seen in post-menopausal women. The Vivelle-Dot drug label comes with the following Black Box Warning: Estrogen-Alone Therapy There is an increased risk of endometrial cancer in a woman with a uterus who uses unopposed estrogens.
Do not use estrogen-alone therapy for the prevention of cardiovascular disease or dementia. The WHI estrogen plus progestin substudy reported increased risks of invasive breast cancer. The WHIMS estrogen plus progestin ancillary study of WHI reported an increased risk of developing probable dementia in postmenopausal women 65 years of age and older.
Do not use estrogen plus progestogen therapy for the prevention of cardiovascular disease or dementia. Start therapy with Vivelle-Dot 0. Estradiol vaginal options include tablets or rings that are inserted directly into the vagina.
An Estradiol patch is prescribed for a number of conditions, many of which relate to menopause. Estradiol may also be used to treat people whose estrogen levels are low for a reason other than menopause or occasionally for other purposes as determined by a medical professional. Anyone who is dealing with any of the conditions listed here or who is at risk for developing postmenopausal osteoporosis might be prescribed hormone therapy in the form of Vivelle Dot.
As noted above, Vivelle Dot may be prescribed for a number of conditions, including menopausal symptoms such as hot flashes, night sweats, and vaginal dryness ; vulvar or vaginal atrophy stemming from menopause; the prevention of postmenopausal osteoporosis; and the management of symptoms associated with low estrogen levels that may not be attributable to menopause.
As you can see, most of the symptoms that might warrant a Vivelle Dot prescription relate in some way to menopause. During menopause, a person's ovaries begin to produce less of the hormones estrogen and progesterone. This can result in a number of physiological changes, some of which may not be pleasant. Vivelle Dot is meant to assist people who are struggling with symptoms that might otherwise interfere with their quality of life.
In some cases, Vivelle Dot may also be prescribed to help prevent osteoporosis. Women may be at an increased risk of developing osteoporosis after menopause because estrogen helps maintain bone health.
The same is true for anyone with lower-than-normal estrogen levels. Decreased estrogen levels may have a negative effect on bone strength and density. Many more Estradiol side effects - mild, moderate, and severe - are possible while using Vivelle Dot.
In some cases, Vivelle Dot may provoke allergic reactions. In addition, it's important to note that Vivelle Dot may increase the risk of several serious health conditions, including:. The products mentioned are trademarks of their respective owners and are not owned by or affiliated with DiscountDrugsFromCanada. Monitor conditions aggravated by fluid retention eg, cardiac or renal impairment ; discontinue if medically concerning fluid retention. Hereditary angioedema. Hepatic hemangiomas.
Do initial complete physical and repeat annually include Pap smear, mammogram, BP. Pregnancy: not indicated. Nursing mothers. May be potentiated by CYP3A4 inhibitors eg, erythromycin, clarithromycin, ketoconazole, itraconazole, ritonavir, and grapefruit juice. Concomitant thyroid replacement; may need to increase thyroid dose. Headache, local reactions eg, erythema, pruritus, rash , back pain, irregular vaginal bleeding, spotting, breast tenderness, nasopharyngitis, sinusitis, upper RTI, depression; thromboembolism, neoplasms, anaphylaxis.
Adult Dosage: Apply to clean, dry, intact skin not to breasts or waist on lower abdomen; rotate application sites. Children Dosage: Not established. Boxed Warning: Endometrial cancer. If it does not stick well, put on a new patch on a different skin area and leave it on only for the rest of your wearing time.
Do not change your patch removal schedule. Remove the patch and apply a new one on the same day s each week to stay on your once-weekly or twice-weekly schedule.
Estradiol may increase your risk of developing a condition that may lead to uterine cancer. Your doctor may prescribe a progestin to help lower this risk.
Report any unusual vaginal bleeding right away. If you need major surgery or will be on long-term bed rest, you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are using estradiol. Your doctor should check your progress on a regular basis to determine whether you should continue this treatment.
Self-examine your breasts for lumps on a monthly basis, and have regular mammograms while using estradiol transdermal. Store patches at room temperature away from moisture and heat. Keep each patch in its pouch until you are ready to use it. After removing a skin patch, fold it in half so it sticks together. Discard the folded patch in a place children and pets cannot get to. If you forget to change your patch, change it as soon as you remember or wait until your next scheduled patch change.
Do not apply two patches at one time.
0コメント