Boniva is also used for this purpose off-label. The study compared once-monthly Boniva to once weekly Fosamax with regard to their ability to increase bone mass density BMD at the lumbar spine and in the total hip. The results showed that once monthly Boniva is non-inferior to Fosamax with regards to this endpoint.
The reduction in bone turnover and gastrointestinal tolerability were also comparable. The results of this randomized, cross-over trial found that significantly more patients prefer the once monthly regimen, with The remainder indicated no preference for one regimen over the other.
This information is not intended to be medical advice. Only your physician can determine which treatment option is most appropriate for your condition. Boniva is a prescription medication that is typically covered by commercial and Medicare insurance plans. Fosamax is a prescription medication that is covered by both commercial and Medicare insurance plans. Bisphosphonates are known for their tendency to cause gastrointestinal side effects such as abdominal pain, nausea, diarrhea, and constipation.
Patients who have a history of gastrointestinal disease may not be candidates for bisphosphonate therapy because they are at a high risk of experiencing these side effects while on bisphosphonate therapy.
These reactions are sometimes severe enough to require hospitalization. Fosamax and Boniva are both known to cause musculoskeletal pains in the bones, muscles, and joints. Boniva has been shown to be associated with increased blood pressure as well as insomnia, or difficulty sleeping. The following chart is not meant to be an all-inclusive list of possible adverse events related to Fosamax and Boniva. Please consult your healthcare provider for a complete list.
When Boniva and Fosamax are given with calcium containing supplements or antacids, the calcium may interfere with the absorption of the Fosamax. Many osteoporosis patients need to take a calcium supplement, therefore it is recommended that you wait a minimum of 30 minutes after taking Fosamax to take calcium or any other oral medications.
Nonsteroidal anti-inflammatory drugs NSAIDs are associated on their own with gastrointestinal side effects similar to bisphosphonates. There is some evidence that giving bisphosphonates with H2-blockers, a form of stomach acid reducers used to treat heartburn, increases the bioavailability of the bisphosphonate drug. This chart does not list every known drug interaction.
Please consult your healthcare professional for a complete list. Dental extractions while on bisphosphonate therapy may increase the risk of developing osteonecrosis of the jaw ONJ , or the gradual death of the jawbone. Prior to starting bisphosphonate therapy, patients should have a dental examination and consider doing any preventive or corrective dental procedures prior to beginning therapy.
Because of their tendency to cause irritation to the mucosa of the esophagus, bisphosphonates should be taken first thing in the morning with a small glass of water. Other medications, drinks, and food should be avoided for at least 30 minutes, but ideally for two hours. Patients should remain upright for at least 30 minutes after taking their dose.
They should not lay down. These precautions will minimize esophageal irritation. Keep in mind that Fosamax and alendronate should be taken first thing in the morning. If you take Fosamax or alendronate once per week, take your missed dose and then go back to taking your dose once a week as told by your doctor.
If you have questions about when to take your next dose after you miss a dose, talk with your doctor or pharmacist. They can recommend the best time to take your next dose. Then your doctor will evaluate your symptoms and test your blood for a period of 6 months to determine if you need another round of treatment.
Other drugs are available that can treat your condition. Some may be a better fit for you than others. They can tell you about other medications that may work well for you. Note: Some of the drugs listed here are used off-label to treat these specific conditions. You may wonder how Fosamax compares with other medications that are prescribed for similar uses. Here we look at how Fosamax and Prolia are alike and different. Fosamax and Prolia belong to different classes of medications.
The medications work slightly differently in the body. Fosamax comes as tablets that are taken by mouth, typically once a week. This injection needs to be done by a healthcare provider, at their office or clinic. Alendronate, the generic form of Fosamax, comes as tablets or as a liquid solution that you take by mouth. Fosamax and Prolia both contain medications that are used to treat osteoporosis. Therefore, these medications can cause very similar side effects, but some different ones as well.
Below are examples of these side effects. These lists contain up to 10 of the most common mild side effects that can occur with Fosamax, with Prolia, or with both drugs when taken individually. These lists contain examples of serious side effects that can occur with Fosamax, with Prolia, or with both drugs when taken individually. But in separate studies, both Fosamax and Prolia were shown to be effective for their approved uses.
In addition, studies have compared treatment with Prolia to that of alendronate, which is the generic form of Fosamax. In a Danish study , people took either alendronate or Prolia to treat their osteoporosis. The study showed that the risk of fracture was about the same when taking either drug.
Over the course of 3 years:. In addition, in a international study , women who had been through menopause took either alendronate or Prolia to treat their osteoporosis. In this study, BMD increased by 3. According to estimates on GoodRx. Fosamax and Prolia are both brand-name drugs. There is currently a generic form of Fosamax called alendronate. Generic medications usually cost less than the brand name forms.
Here we look at how Fosamax and Boniva are alike and different. Fosamax and Boniva belong to a class of medications called bisphosphonates.
Fosamax is available as the generic drug alendronate. And Boniva is available as the generic drug ibandronate. The generic is considered to be as safe and effective as the original drug.
Osteoporosis is a condition that causes brittle, weak bones. The generic form of Fosamax, alendronate, comes as tablets and as a liquid solution. Both forms of alendronate are taken by mouth. Boniva and its generic form, ibandronate, come as tablets that are taken by mouth, typically once a month.
Fosamax and Boniva both contain medications to treat osteoporosis in postmenopausal women. These lists contain up to 10 of the most common mild side effects that can occur with Fosamax, with Boniva, or with both drugs when taken individually.
These lists contain examples of serious side effects that can occur with Fosamax, with Boniva, or with both drugs when taken individually. The use of Fosamax and Boniva tablets in treating osteoporosis has not been directly compared in clinical studies. Alendronate is the generic form of Fosamax. And ibandronate is the generic form of Boniva. In this trial, women took either alendronate once a week by mouth or ibandronate once a month by mouth.
The results showed that both generic drugs were effective at treating osteoporosis in this group of women. Fosamax and Boniva are both brand-name drugs. There are currently generic forms of both drugs. The generic form of Fosamax is called alendronate. The generic form of Boniva is called ibandronate. Brand-name medications usually cost more than generics. However, treatments such as Fosamax may help relieve symptoms and keep these conditions from getting worse. For example, if you have osteoporosis, Fosamax can reduce your risk of fractures and increase your bone mineral density BMD.
BMD is a measurement of how strong your bones are. Also, Fosamax continues to work to decrease your bone breakdown even after you stop taking it. Stopping other medications that treat or prevent osteoporosis, such as Prolia , may cause side effects.
These side effects can include bone loss and an increased risk of fractures. Fosamax belongs to a class of medications called bisphosphonates. However, another study in the United Kingdom showed that the risk of esophageal cancer was about doubled in people who filled their bisphosphonate prescription at least 10 times. This was in comparison to people who filled their bisphosphonate prescription between 1 and 9 times.
The risk of esophageal cancer was also about doubled in people who took a bisphosphonate medication for at least 3 years. This is because very few clinical trials have been done to determine if strontium can be used for osteoporosis. In the United States, strontium is available as strontium citrate and strontium chloride.
These names refers to the form of salt used to make each strontium supplement. This drug used to be used for osteoporosis treatment. After reviewing studies in which strontium ranelate was used to treat osteoporosis, the drug was found to increase the risk of heart attack and blood clots. In , strontium ranelate became available in the United Kingdom by prescription only.
And people taking it must be monitored by their doctor during treatment. If you have questions about strontium supplements, talk with your doctor about the best treatment options for you. Fosamax and thyroid medications should both be taken in the morning when your stomach is empty.
But you should take Fosamax before you take your thyroid medication. Specifically, you should take Fosamax at least 30 minutes before you eat, drink, or take any other medications. After you take Fosamax, wait 30 minutes. Then take your thyroid medication and wait another 30 to 60 minutes before eating breakfast. Always talk with your doctor before you stop taking any medications.
Gradually reducing your dosage helps your body adjust to the change. Fosamax was found to be just as safe for older adults as it was for younger adults. However, in some cases, older adults may be more sensitive to the medication and may have a higher risk of side effects. Before taking Fosamax, talk with your doctor about your health history.
Fosamax may not be right for you if you have certain medical conditions or other factors affecting your health. These include:. However, chronic long-lasting excessive alcohol use may have a negative effect on your bones, and Fosamax is used to treat certain bone conditions. According to the National Institute of Arthritis and Musculoskeletal and Skin Diseases , alcohol use may increase your risk of developing osteoporosis.
And if you have osteoporosis, drinking alcohol may worsen the condition. This is because alcohol can affect how your body uses calcium and vitamin D , which are nutrients your body uses to build and maintain strong bones. Alcohol can also cause changes in hormone levels in men and women. In men, alcohol may decrease testosterone. And in women, alcohol may decrease estrogen. These hormonal changes also increase your risk of osteoporosis. In addition, keep in mind that you should always wait at least 30 minutes after taking Fosamax before having drinks, foods, or other medications.
This includes consuming alcohol. Fosamax can interact with several other medications. It can also interact with certain supplements as well as certain foods. Different interactions can cause different effects. For instance, some interactions can interfere with how well a drug works. Other interactions can increase side effects or make them more severe. Fosamax should be taken at least 30 minutes before any other medications, foods, or drinks. Below are some of the medications that can interact with Fosamax.
Before taking Fosamax, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use.
Sharing this information can help you avoid potential interactions. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. This is because antacids decrease the amount of Fosamax that your body can absorb. For example, in clinical trials , people taking aspirin with more than 10 milligrams mg of Fosamax per day had an increased risk of digestive side effects.
These side effects included irritation of the stomach and intestines, heartburn, and nausea. However, this increased risk was not seen in people who took 10 mg or less of Fosamax per day. Before taking Fosamax, talk with your doctor about any other medications that you take. If you take aspirin, your doctor may recommend a medication other than Fosamax to treat your condition. The digestive tract refers to the parts of the body involved in eating and digesting foods and liquids.
This irritation may increase your risk of digestive side effects from Fosamax and NSAIDs, such as nausea or belly pain. This was in comparison with people taking a placebo, which is a treatment with no active drug. But your doctor may monitor you more often during treatment just in case you have increased side effects. Using certain supplements with Fosamax could make Fosamax less able to treat your condition.
Below, we describe a type of supplement that may interact with Fosamax in this way. But keep in mind that you should take any supplements at least 30 minutes after taking Fosamax.
And only take a calcium and vitamin D supplement if your doctor recommends it. You should take Fosamax at least 30 minutes before consuming any food, drinks, or other medications. Taking Fosamax with these other substances can prevent your body from properly absorbing Fosamax.
Taking Fosamax with a beverage other than plain water can decrease how much Fosamax your body absorbs. For the best results, take these pills at the same time every day. Take it on an empty stomach with a full glass of water , at least two hours after, or a full half hour before eating.
Do not take it in combination with other medications or any vitamin or food supplements. Individuals with untreated calcium deficiency or esophageal disease should not use this treatment.
This includes prescription and non-prescription medicines as well as vitamins and herbal supplements.
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